Production and biological activity of marcellomycin, an antitumor anthracycline antibiotic, and taxonomy of the producing organism.
نویسندگان
چکیده
An actinomycete, isolated from a soil sample from Ontario, Canada, was studied taxonomically and named Actinosporangium bohemicum sp. nov. strain C-36,145. This strain was found to produce a complex mixture of e-pyrromycinone glycosides having antitumor properties. Marcellomycin, a member of this complex, was selected for further study. Conditions for production of this antibiotic were developed in flask studies and scaled-up to the 3,000-liter fermentor stage.
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عنوان ژورنال:
- The Journal of antibiotics
دوره 35 9 شماره
صفحات -
تاریخ انتشار 1982